CD5 Antibody

Catalog Number:

46437

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P06127
NCBI Gene ID:921
NCBI Protein:NP_055022

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human CD5

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CD5 protein.

Applications:

IHC

Background:

CD5 (also designated Lyt-1) has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/ CD3-ζ chain and with the Src family kinase Lck p56.?In vitro?studies have shown a 10- to 15-fold increase in the kinase activity of Lck bound to CD5. The B cell antigen, CD72, serves as a receptor for CD5. The consequence of CD5 binding to its cognate receptor is still in question and likely plays a role in thymic selection. May act as a receptor in regulating T-cell proliferation.

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF