CCM2 Antibody

Catalog Number:

46424

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9BSQ5
NCBI Gene ID:83605
NCBI Protein:BC004903

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human CCM2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CCM2 protein.

Applications:

IHC

Background:

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF