CASR Antibody

Catalog Number:

46408

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P41180
NCBI Gene ID:846
NCBI Protein:BC112236

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human CASR

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CASR protein.

Applications:

WB IHC

Background:

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 50-300

Datasheet PDF