CASP4 Antibody

Catalog Number:

46405

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P49662
NCBI Gene ID:837
NCBI Protein:NP_001216

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human CASP4

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CASP4 protein.

Applications:

IHC

Background:

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF