CARD16 Antibody

Catalog Number:

46403

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q5EG05
NCBI Gene ID:114769
NCBI Protein:NP_001017534

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human CARD16

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CARD16 protein.

Applications:

WB IHC

Background:

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1: 40-200

Datasheet PDF