CAPN10 Antibody

Catalog Number:

46397

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9HC96
NCBI Gene ID:11132
NCBI Protein:NP_075571

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human CAPN10

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CAPN10 protein.

Applications:

WB

Background:

Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.

References:

appl_detail:

Western blotting: 1:200-1:1000

Datasheet PDF