CACNA2D2 Antibody

Catalog Number:

46384

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9NY47
NCBI Gene ID:9254
NCBI Protein:NP_001167522

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human CACNA2D2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CACNA2D2 protein.

Applications:

IHC

Background:

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.?

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF