C7 Antibody

Catalog Number:

46376

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P10643
NCBI Gene ID:730
NCBI Protein:BC063851

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human C7

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total C7 protein.

Applications:

WB

Background:

The complement cascade is a multi-protein system that functions to clear pathogens from an infected host. Part of the innate (unchanging) immune system, the complement cascade consists of proteins and inactive zymogens that are present in blood and are stimulated by one of several triggers. Once stimulated, the cascade relays amplified responses throughout the body, ultimately activating the cell-killing membrane attack complex which can insert itself into the cell membrane and cause the cell to lyse. C7 (complement component 7) is an 843 amino acid secreted protein that participates in the formation of membrane attack complex (MAC), a complex that forms pores in the plasma membrane of target cells for innate and adaptive immune responses. As a membrane anchor, C7 exists as a monomer or dimer and can form multimeric rosettes with C5β. C7 defects are the cause of component C7 deficiency (C7D), characterized by recurrent bacterial infections caused by Neisseria meningitidis.

References:

appl_detail:

Western blotting: 1:500-1:2000

Datasheet PDF