C4BPB Antibody

Catalog Number:

46374

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P20851
NCBI Gene ID:725
NCBI Protein:BC005378

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human C4BPB

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total C4BPB protein.

Applications:

IHC

Background:

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.?

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF