C3/C3b Antibody

Catalog Number:

46372

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P01024
NCBI Gene ID:718
NCBI Protein:NP_000055

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human C3,C3b

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total C3/C3b protein.

Applications:

IHC

Background:

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF