C1orf101 Antibody

Catalog Number:

46367

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q5SY80
NCBI Gene ID:257044
NCBI Protein:BC032859

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human C1orf101

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total C1orf101 protein.

Applications:

IHC

Background:

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf101 gene product has been provisionally designated C1orf101 pending further characterization.

References:

appl_detail:

Immunohistochemistry: 1: 50-300

Datasheet PDF