C14orf80 Antibody

Catalog Number:

46362

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q86SX3
NCBI Gene ID:283643
NCBI Protein:BC016028

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Full length fusion protein of human C14orf80

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total C14orf80 protein.

Applications:

WB IHC

Background:

C14orf80 (chromosome 14 open reading frame 80) is a 495 amino acid protein that exists as four alternatively spliced isofoms. The gene encoding C14orf80 maps to human chromosome 14q32.33. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?1-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 25-100

Datasheet PDF