BBS10 Antibody

Catalog Number:

46336

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8TAM1
NCBI Gene ID:79738
NCBI Protein:BC026355

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human BBS10

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total BBS10 protein.

Applications:

WB IHC

Background:

This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 30-150

Datasheet PDF