ATN1 Antibody

Catalog Number:

46321

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P54259
NCBI Gene ID:1822
NCBI Protein:NP_001931

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human ATN1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ATN1 protein.

Applications:

IHC

Background:

Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.

References:

appl_detail:

Immunohistochemistry: 1: 40-200

Datasheet PDF