ACKR2 Antibody

Catalog Number:

46304

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O00590
NCBI Gene ID:1238
NCBI Protein:NP_001287

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human ACKR2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ACKR2 protein.

Applications:

WB IHC

Background:

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 30-150

Datasheet PDF