GPR18 antibody

Catalog Number:

44280

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P17038
NCBI Gene ID: NP_005283

Form of Antibody:

pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Storage/Stability:

Immunogen:

Synthetic peptide of human GPR18

Purification:

Antigen affinity purification

Specificity/Sensitivity:

Applications:

IHC

Background:

Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).

References:

appl_detail:

IHC dilution:1:25-1:50

Datasheet PDF