BLVRB Antibody

Catalog Number:

43993

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P30043
NCBI Gene ID: 645

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human BLVRB

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total BLVRB protein.

Applications:

IHC WB

Background:

BLVRB (biliverdin reductase B or BVR-B), also known as flavin reductase (FR), NADPH-dependent diaphorase, Biliverdin-IX ¡Ò-reductase or green heme-binding protien (GHBP) is an enzyme involved in fetal heme metabolism. It is dependent on NADPH and is responsible for catalyzing the transfer of electrons to flavins from reduced pyridine nucleotides. BLVRB exists as a monomer, localizes to the cytoplasm and is highly expressed in fetal liver and adult erythrocytes and, to a lesser extent, in heart, lung, cerebrum and adrenal gland. In liver, BLVRB functions to convert biliverdin (isoforms IX¡Ò, IX? and IX?) to bilirubin. BLVRB contains one binding site for all of its substrates and predominantly interacts with them through hydrophobic interactions. BLVRB also exhibits ferric reductase activity. In addition, it is commonly used as a reliable marker for NOS.

References:

appl_detail:

Western blotting: 1:500-2000
Immunohistochemistry: 1: 100-200

Datasheet PDF