BHLHA15 Antibody

Catalog Number:

43992

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q7RTS1
NCBI Gene ID: 168620

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human BHLHA15

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total BHLHA15 protein.

Applications:

IHC WB

Background:

MIST1 (muscle, intestine and stomach expression 1), also known as BHLHB8 (basic helix-loop-helix domain containing, class B, 8), is a 189 amino acid nuclear protein expressed in liver, brain, skeletal muscle and spleen. MIST1 contains a basic helix-loop-helix (bHLH) domain and belongs to the bHLH family of transcription factors. Members of this family bind to the E-box motifs present in the promoter or enhancer regions of a variety of developmentally regulated genes and function as either transcriptional activators or transcriptional repressors. MIST1 is capable of binding to E-box motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) and is believed to play a role regulating the transcriptional activity of MyoD, a protein involved in the regulation of muscle cell development. More specifically, MIST1 functions as a repressor of MyoD activity, ensuring that myoblast populations do not differentiate. In addition, MIST1 is expressed in mammary epithelial cells and is essential for the regulation of mammary gland development.

References:

appl_detail:

Western blotting: 1:200-1000
Immunohistochemistry: 1: 20-100

Datasheet PDF