IWS1 Antibody

Catalog Number:

43981

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q96ST2
NCBI Gene ID: 55677

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human IWS1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total IWS1 protein.

Applications:

IHC

Background:

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF