ZBTB10 Antibody

Catalog Number:

43967

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q96DT7
NCBI Gene ID: 65986

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human ZBTB10

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ZBTB10 protein.

Applications:

IHC WB

Background:

RINZF, also known as ZBTB10 (zinc finger and BTB domain containing protein 10), is a 847 amino acid protein that contains one BTB/POZ domain and two C2H2-type zinc fingers. Localized to the nucleus, RINZF is believed to play a role in transcriptional regulation. Specifically, RINZF is capable of binding to the CACC element of the Gastrin promoter. In this regard, RINZF competes with Sp1 for CACC binding and interferes with Sp1 transactivation, thereby regulating Gastrin gene expression. The rat RINZF protein shares 98% homology with the human RINZF protein, suggesting that RINZF is a conserved protein. Due to alternative splicing events, two RINZF isoforms exist. In addition, RINZF may be phosphorylated by ATR or ATM upon DNA damage.

References:

appl_detail:

Western blotting: 1:500-2000
Immunohistochemistry: 1: 100-300

Datasheet PDF