HUWE1 Antibody

Catalog Number:

43961

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q7Z6Z7
NCBI Gene ID: 10075

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human HUWE1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total HUWE1 protein.

Applications:

IHC

Background:

This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.

References:

appl_detail:

Immunohistochemistry: 1: 10-50

Datasheet PDF