MLANA Antibody

Catalog Number:

43951

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q16655
NCBI Gene ID: 2315

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human MLANA

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total MLANA protein.

Applications:

IHC

Background:

Melan-A (also designated MART-1) is a melanocyte differentiation antigen that is specific to melanomas, melanocyte cell lines and retina. Melan-A peptide is recognized by most HLA-A2-restricted tumor-specific tumor-infiltrating lymphocytes in patients with melanoma. Antimelanoma cytotoxic T lymphocytes can be generated with a Melan-A peptide, implicating Melan-A as a potential candidate for antigen-specific immunotherapy in melanoma patients. Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

References:

appl_detail:

Immunohistochemistry: 1: 100-250

Datasheet PDF