LAT Antibody

Catalog Number:

43949

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O43561
NCBI Gene ID: 27040

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human LAT

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total LAT protein.

Applications:

IHC WB

Background:

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

References:

appl_detail:

Western blotting: 1:200-1000
Immunohistochemistry: 1: 20-100

Datasheet PDF