BAGE2 Antibody

Catalog Number:

43843

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q86Y30
NCBI Gene ID: 85319

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human BAGE2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total BAGE2 protein.

Applications:

WB

Background:

Members of the BAGE gene family encode antigens that are recognized by cytotoxic T lymphocytes and are also known as CT (cancer/testis) antigens. Generated by juxtacentromeric shuffling of the MLL3 gene, the ancestral BAGE gene was expanded by acrocentric exchanges and/or juxtacentromeric movements.Generally, BAGE proteins are silent in all normal tissues with the exception of testis. BAGE2 and BAGE 3 (B melanoma antigen 2 and 3, respectively), also known as Cancer/testis antigen 2.2 and 2.3 (respectively), are 109 amino acid secreted proteins that are expressed in 22% of melanomas, lung and bladder carcinomas, and are also expressed in normal testis tissue. Like the genes encoding MAGE proteins, BAGE genes are most likely silenced by DNA methylation and/or chromatin compaction in normal tissues other than testis.

References:

appl_detail:

Western blotting: 1:200-1000

Datasheet PDF