ERBB4 Antibody

Catalog Number:

43833

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q15303
NCBI Gene ID: 2066

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human ERBB4

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ERBB4 protein.

Applications:

IHC

Background:

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF