WISP2 Antibody

Catalog Number:

43815

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O76076
NCBI Gene ID: 8839

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human WISP2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total WISP2 protein.

Applications:

IHC

Background:

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.?

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF