PYM1 Antibody

Catalog Number:

43811

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9BRP8
NCBI Gene ID: 84305

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human PYM1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PYM1 protein.

Applications:

IHC

Background:

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547?did not detect RNA-binding activity independently of the EJC.

References:

appl_detail:

Immunohistochemistry: 1: 10-50

Datasheet PDF