WRN Antibody

Catalog Number:

43808

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q14191
NCBI Gene ID: 7486

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human WRN

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total WRN protein.

Applications:

IHC

Background:

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF