ZNF143 Antibody

Catalog Number:

43787

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P52747
NCBI Gene ID: 7702

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human ZNF143

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ZNF143 protein.

Applications:

IHC

Background:

ZNF143 (zinc finger protein 143), also known as SBF, STAF or pHZ-1, is a 626 amino acid protein that contains seven C2H2-type zinc fingers and belongs to the GLI (glioma-associated oncogene) C2H2-type zinc-finger family. Localized to the nucleus and expressed ubiquitously with highest expression in ovaries, ZNF143 functions as a transcriptional activator that, via its C2H2-type zinc domains, binds to the SPH motif found in the promotors of small nuclear RNAs (snRNA). Through its ability to bind the promotors of various snRNA genes, ZNF143 controls the subsequent expression of the corresponding protein products. ZNF143 expression is induced upon DNA damage, suggesting an important role for ZNF143 in DNA repair events.

References:

appl_detail:

Immunohistochemistry: 1: 10-50

Datasheet PDF