PAPPA-AS1 Antibody

Catalog Number:

43780

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q5QFB9
NCBI Gene ID: 493913

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human PAPPA-AS1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PAPPA-AS1 protein.

Applications:

IHC

Background:

PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF