PFKFB3 Antibody

Catalog Number:

43773

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q16875
NCBI Gene ID: 5209

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human PFKFB3

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PFKFB3 protein.

Applications:

WB

Background:

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

References:

appl_detail:

Western blotting: 1:200-1000

Datasheet PDF