KCNQ3 Antibody

Catalog Number:

43764

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O43525
NCBI Gene ID: 3786

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human KCNQ3

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total KCNQ3 protein.

Applications:

IHC

Background:

This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF