INSR Antibody

Catalog Number:

43738

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P06213
NCBI Gene ID: 3643

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human INSR

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total INSR protein.

Applications:

IHC

Background:

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF