CASC5 Antibody

Catalog Number:

43703

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8NG31
NCBI Gene ID: 57082

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human CASC5

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CASC5 protein.

Applications:

IHC

Background:

The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.?

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF