ALS2CL Antibody

Catalog Number:

43697

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q60I27
NCBI Gene ID: 259173

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human ALS2CL

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ALS2CL protein.

Applications:

IHC

Background:

Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2), infantile onset ascending hereditary spastic paralysis (IAHSP) and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein, which is associated with small, punctate membrane structures. Therefore Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal like protein (ALS2CL) also modulates Rab5 activity.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF