KRTAP11-1 Antibody

Catalog Number:

43665

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8IUC1
NCBI Gene ID: 337880

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human KRTAP11-1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total KRTAP11-1 protein.

Applications:

WB

Background:

Hair is a structure that is unique to mammals. It plays an important role in the retention of heat, as well as sexual dimorphism, attraction of mates and protection of skin. The major components of hair are ?-keratins and keratin-associated proteins (KRTAPs or KAPs), each of which are encoded by multigene families. Hair keratins form an intermediate filament (IF) network, which is embedded in an interfilamentous matrix consisting of KRTAPs. KRTAPS comprise three major groups, which are essential for the formation of rigid and resistant hair shafts through disulfide bond cross-linking or hydrophobic interactions with keratins. These groups are designated high cysteine (HS), which includes subfamilies 1, 2, 3, 10, 12, 16, 29 and 31, ultrahigh cysteine, including subfamilies 4, 5, 9, 17, 28, 30, 32 and 33, and high glycine-tyrosine (HGT), which includes subfamilies 6, 7, 8, 19, 20 and 21. In addition, subfamilies 11, 13, 24-27, 29, 34 and 35 have high serine content but relative low cysteine content. After further phylogenetic studies, subfamilies 14 and 15 have been grouped with subfamily 13 and subfamily 22 was combined with subfamily 19.

References:

appl_detail:

Western blotting: 1:200-1000

Datasheet PDF