GANAB Antibody

Catalog Number:

43659

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q14697
NCBI Gene ID: 23193

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human GANAB

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total GANAB protein.

Applications:

IHC

Background:

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF