CLDN12 Antibody

Catalog Number:

43652

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P56749
NCBI Gene ID: 9069

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human CLDN12

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CLDN12 protein.

Applications:

IHC

Background:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF