SMC5 Antibody

Catalog Number:

43637

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8IY18
NCBI Gene ID: 23137

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human SMC5

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total SMC5 protein.

Applications:

IHC

Background:

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF