IL6ST Antibody

Catalog Number:

43623

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P40189
NCBI Gene ID: 3572

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human IL6ST

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total IL6ST protein.

Applications:

IHC

Background:

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF