UNC13B Antibody

Catalog Number:

43616

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O14795
NCBI Gene ID: 10497

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human UNC13B

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total UNC13B protein.

Applications:

IHC

Background:

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

References:

appl_detail:

Immunohistochemistry: 1: 100-300

Datasheet PDF