ZNF131 Antibody

Catalog Number:

43572

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P52739
NCBI Gene ID: 7690

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human ZNF131

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ZNF131 protein.

Applications:

IHC WB

Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr¨¹ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF131 (Zinc finger protein 131) is a 623 amino acid nuclear protein that contains one BTB (POZ) domain and six C2H2-type zinc fingers. With predominant expression found in brain, it is likely that ZNF131 plays a role as a transcription regulator during development and organogenesis of the adult central nervous system. ZNF131 also represses ER? (Estrogen receptor alpha)-mediated transactivation by interrupting ER? binding to the estrogen-response element. There are two isoforms of ZNF131 that are produced as a result of alternative splicing events.

References:

appl_detail:

Western blotting: 1:200-1000
Immunohistochemistry: 1: 20-100

Datasheet PDF