ATF6B Antibody

Catalog Number:

43545

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q99941
NCBI Gene ID: 1388

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human ATF6B

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ATF6B protein.

Applications:

IHC WB

Background:

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Western blotting: 1:200-1000
Immunohistochemistry: 1: 20-100

Datasheet PDF