MCM10 Antibody

Catalog Number:

43512

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q7L590
NCBI Gene ID: 55388

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human MCM10

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total MCM10 protein.

Applications:

IHC

Background:

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

References:

appl_detail:

Immunohistochemistry: 1: 100-200

Datasheet PDF