SLC7A11 Antibody

Catalog Number:

43437

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UPY5
Gene ID: 23657

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human SLC7A11

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SLC7A11 protein.

Applications:

WB IHC

Background:

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

References:

appl_detail:

Western blotting: 1:500-1:2000

Immunohistochemistry: 1:20-1:100

Datasheet PDF