COMMD10 Antibody

Catalog Number:

43383

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9Y6G5
Gene ID: 51397

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human COMMD10

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total COMMD10 protein.

Applications:

IHC

Background:

The COMMD family represents a group of evolutionary conserved proteins that share a common COMM domain at their extreme C-terminus, which provides an interface for protein-protein interactions. COMMD10 (COMM domain containing 10), also known as PTD002 or HSPC305, is a 202 amino acid protein that belongs to the COMMD family and contains one COMM domain. The gene encoding COMMD10 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B.

References:

appl_detail:

Immunohistochemistry: 1:20-1:100

Datasheet PDF