SIAH1 Antibody

Catalog Number:

43329

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8IUQ4
Gene ID: 6477

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Full length fusion protein of human SIAH1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SIAH1 protein.

Applications:

WB IHC

Background:

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:30-1:150

Datasheet PDF