RCC1 Antibody

Catalog Number:

43140

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P18754
Gene ID: 1104

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human RCC1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RCC1 protein.

Applications:

WB

Background:

RCC1 (regulator of chromosome condensation 1), increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A protein designated Ran BP1 has no intrinsic GAP activity and functions as a GEF inhibitor, deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. Ran BP2 has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1:30-1:150

Datasheet PDF