PDCD6IP Antibody

Catalog Number:

43906

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8WUM4
NCBI Gene ID: 10015

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human PDCD6IP

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PDCD6IP protein.

Applications:

WB

Background:

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

References:

appl_detail:

Western blotting: 1:200-1000

Datasheet PDF