SLC12A3 Antibody

Catalog Number:

43712

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P55017
NCBI Gene ID: 6559

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human SLC12A3

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total SLC12A3 protein.

Applications:

IHC

Background:

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.?

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF